Journal: Frontiers in Microbiology

Article Title: Resistant Maltodextrin Intake Reduces Virulent Metabolites in the Gut Environment: A Randomized Control Study in a Japanese Cohort

doi: 10.3389/fmicb.2022.644146

Figure Lengend Snippet: Experimental design of the study and comprehensive analysis of gut microbiome and metabolome profiles. (A) Flow diagram of the double-blind, placebo-controlled parallel group study. Fecal and blood samples were collected 0 and 24 weeks after test food (resistant maltodextrin: RMD) or control food (normal maltodextrin: MD) intervention. Gut microbiome and metabolome analyses, oral glucose tolerance test (OGTT), and blood tests were conducted. (B) Box plot representing distribution of unweighted UniFrac distance for the gut microbiome profiles among the samples from different subjects at the same time point (inter 0 week) and the distance between the samples from the same subject in the control group and RMD group (** p < 0.005, *** p < 0.0005; the Dunn’s test). (C) Box plot representing the distribution of the Spearman’s correlation distance for intestinal metabolome profiles among the samples from different subjects at the same time point (inter 0 week) and the distance between the samples from the same subject in the control group and RMD group (** p < 0.005, *** p < 0.0005; the Dunn’s test).

Article Snippet: The intestinal environment was assessed by a metabologenomics approach, involving 16S rRNA gene-based microbiome analysis and mass spectrometry-based metabolome analysis.

Techniques: Maltodextrin, Control